Kurita A, Hasunuma T, Mochio S, Shimada T, Isogai Y, Kurahashi T
Third Department of Internal Medicine, Jikei University School of Medicine, Tokyo.
Intern Med. 1994 Jun;33(6):373-5. doi: 10.2169/internalmedicine.33.373.
A 39-year-old man was admitted because of an abrupt onset of right-side weakness and dysarthria. During the 2 years before admission, he had suffered from insomnia, depressed mood and progressive memory disturbance. Neurological and psychiatric examination revealed severe intellectual impairment in addition to the neurological deficits. Neuroradiological examinations revealed multiple brain infarcts. He had no risk factor for stroke except for lupus anticoagulant. He was diagnosed as having multi-infarct dementia associated with antiphospholipid antibodies. This case suggests that it is necessary to investigate antiphospholipid antibodies in addition to neuroradiological examination when relatively young patients present with unexplained cognitive or behavioral symptoms.
一名39岁男性因突发右侧肢体无力和构音障碍入院。入院前2年，他一直患有失眠、情绪低落和进行性记忆障碍。神经和精神检查发现，除了神经功能缺损外，还存在严重的智力损害。神经放射学检查发现多处脑梗死。除狼疮抗凝物外，他没有中风的危险因素。他被诊断为与抗磷脂抗体相关的多发梗死性痴呆。该病例表明，当相对年轻的患者出现无法解释的认知或行为症状时，除了进行神经放射学检查外，还需要检测抗磷脂抗体。
