Iriyama K, Carpentier Y A
Second Department of Surgery, Mie University School of Medicine, Tsu, Japan.
Nutrition. 1994 May-Jun;10(3):252-4.
Triacylglycerol (TG)-rich particles in parenteral lipid emulsion have been designed to mimic chylomicrons (CMs), which are exogenous dietary TG-rich lipoproteins. Over the past 30 yr, since lipid emulsions were first used for parenteral nutrition, it has been generally accepted that the intravascular metabolism of TG-rich particles in an emulsion is similar to that of CMs. Both the particles in an emulsion and CMs have a TG core that is stabilized by a surface layer of phospholipids. However, there are major differences between the two types of particles regarding their composition of protein moieties. CMs contain and acquire apolipoproteins, which are essential for the regulation of their intravascular metabolism. In contrast, the TG-rich particles in an emulsion do not contain any apolipoprotein. It has been demonstrated that the particles in an emulsion also acquire various kinds of apolipoprotein during their brief intravascular life. Thus, they may be subject to intravascular metabolic processes similar to those of CMs. In this review, we describe the mechanism by which TG-rich particles in an emulsion acquire apolipoproteins from the perspective of parenteral nutrition with lipid emulsions.
肠外营养脂质乳剂中富含三酰甘油（TG）的颗粒被设计用于模拟乳糜微粒（CMs），后者是外源性富含膳食TG的脂蛋白。在过去30年里，自从脂质乳剂首次用于肠外营养以来，人们普遍认为乳剂中富含TG的颗粒在血管内的代谢与CMs相似。乳剂中的颗粒和CMs都有一个由磷脂表面层稳定的TG核心。然而，这两种颗粒在蛋白质部分组成方面存在重大差异。CMs含有并获取载脂蛋白，这对其血管内代谢的调节至关重要。相比之下，乳剂中富含TG的颗粒不含有任何载脂蛋白。已经证明，乳剂中的颗粒在其短暂的血管内生存期也会获取各种载脂蛋白。因此，它们可能会经历与CMs类似的血管内代谢过程。在这篇综述中，我们从使用脂质乳剂进行肠外营养的角度描述乳剂中富含TG的颗粒获取载脂蛋白的机制。
