LiVolsi V A, Asa S L
Department of Pathology, University of Pennsylvania, Philadelphia.
Thyroid. 1994 Summer;4(2):233-6. doi: 10.1089/thy.1994.4.233.
Over the past several decades, iodide supplementation to food supplies in many parts of the world has been followed by a corresponding decrease in the incidence of follicular thyroid carcinoma. However, pathologists continue to over-diagnose this tumor. Benign lesions (e.g., partly encapsulated hyperplastic nodules, pseudoinvasion after fine needle aspiration), and malignancies (especially the follicular variant of papillary carcinoma) have been misinterpreted as follicular carcinoma. Since the clinical features and biological behavior of true follicular cancer differ from the entities with which it may be confused, it is essential that appropriate histological criteria be applied to the diagnostic interpretation of thyroid nodules that exhibit follicular architecture. Only in this way will it be possible to define prognosis and to evaluate treatment options.
在过去几十年里，世界上许多地区在食物供应中添加碘之后，滤泡性甲状腺癌的发病率相应下降。然而，病理学家仍在过度诊断这种肿瘤。良性病变（如部分包膜化的增生性结节、细针穿刺后的假浸润）以及恶性肿瘤（尤其是乳头状癌的滤泡变体）都被误诊为滤泡性癌。由于真正的滤泡性癌的临床特征和生物学行为与可能与之混淆的病变不同，因此必须将适当的组织学标准应用于对呈现滤泡结构的甲状腺结节的诊断解读。只有这样，才有可能确定预后并评估治疗方案。
