Sato M, Furukawa F, Nishikawa A, Imazawa T, Yoshimura H, Suzuki J, Nakamura K, Takahashi M
Eisei Shikenjo Hokoku. 1993(111):34-8.
This study was undertaken to investigate the effects of cyclophosphamide (CP) on spontaneous pancreatitis and testicular atrophy of WBN/Kob rats. CP was given daily in drinking water to groups of 20 male 6-week-old WBN/Kob rats at doses of 0 (control), 1.25 or 2.5 mg/kg for 20 weeks. The final body weight in the 2.5 mg/kg CP group was significantly lower than that in the control group. There were no significant differences in blood glucose levels and weights of the pancreas and testis between groups. On histopathological examinations, pancreatitis and testicular atrophy were noted in each group. However, the incidence of pancreatitis characterized by inflammatory cell infiltration and fibrosis in the 2.5 mg/kg CP group was significantly decreased as compared to the control group. In contrast, testicular atrophy was more severe in the 2.5 mg/kg CP group than in the control group. Thus the results demonstrated that CP has inhibitory effects on the development of pancreatitis and enhancing effects on the development of testicular atrophy in WBN/Kob rats.
本研究旨在探讨环磷酰胺（CP）对WBN/Kob大鼠自发性胰腺炎和睾丸萎缩的影响。将20只6周龄雄性WBN/Kob大鼠分为几组，每日通过饮用水给予CP，剂量分别为0（对照组）、1.25或2.5mg/kg，持续20周。2.5mg/kg CP组的最终体重显著低于对照组。各组之间的血糖水平以及胰腺和睾丸重量均无显著差异。组织病理学检查发现，每组均出现胰腺炎和睾丸萎缩。然而，与对照组相比，2.5mg/kg CP组以炎症细胞浸润和纤维化为特征的胰腺炎发生率显著降低。相反，2.5mg/kg CP组的睾丸萎缩比对照组更严重。因此，结果表明CP对WBN/Kob大鼠胰腺炎的发展具有抑制作用，而对睾丸萎缩的发展具有促进作用。
