Kohli Y, Kato T, Ito S
Second Department of Internal Medicine, Fukui Medical School, Japan.
J Gastroenterol. 1994 Jul;29 Suppl 7:105-9.
Phenol red dye spraying endoscopy, in addition to a biopsy study, was employed for the determination of Helicobacter pylori distribution on the gastric mucosa of 108 patients with no gross gastric findings. The sensitivity of this method was 100%, and its specificity was 84.6%. In patients with a C0 pattern of the fundic-pyloric (F-P) border, the H. pylori-positive rate was only 21%, but this increased with the spread of atrophic mucosa, to approximately 90%. However, in patients with an O3 pattern, H. pylori could not be found. In addition, in 24 (80.0%) of 30 patients with no glandular atrophy, this organism was not found, while, in contrast, the organism was demonstrated in 54 (85.8%) of 63 patients with a slight degree of glandular atrophy. In patients with severe mucosal atrophy accompanying intestinal metaplasia, however, the organism was not found. One-half of the patients examined were followed up, using this technique. In those who were H. pylori-negative, glandular atrophy remained unchanged, while advanced glandular atrophy was seen in 10 (28.6%) of 35 H. pylori-positive patients. A cephalad shift of the F-P border was observed in 20 (57.1%) of these 35 H. pylori-positive patients, while in those who were negative, the F-P border remained unchanged, with one exception.
除活检研究外，还采用酚红染料喷洒内镜检查法，以确定108例无明显胃部病变患者胃黏膜上幽门螺杆菌的分布情况。该方法的敏感性为100%，特异性为84.6%。在胃底-幽门（F-P）边界呈C0型的患者中，幽门螺杆菌阳性率仅为21%，但随着萎缩性黏膜范围的扩大，该阳性率增加至约90%。然而，在呈O3型的患者中未发现幽门螺杆菌。此外，在30例无腺体萎缩的患者中，有24例（80.0%）未发现该菌，而相比之下，在63例有轻度腺体萎缩的患者中，有54例（85.8%）检测到该菌。然而，在伴有肠化生的严重黏膜萎缩患者中未发现该菌。对一半接受检查的患者采用该技术进行了随访。在幽门螺杆菌阴性的患者中，腺体萎缩情况保持不变，而在35例幽门螺杆菌阳性的患者中，有10例（28.6%）出现了重度腺体萎缩。在这35例幽门螺杆菌阳性的患者中，有20例（57.1%）观察到F-P边界上移，而在阴性患者中，除1例例外，F-P边界保持不变。
