Vasen H F, van Erpecum K J, Roelfsema F, Raue F, Koppeschaar H, Griffioen G, van Berge Henegouwen G P
Department of Endocrinology, Utrecht University Hospital, The Netherlands.
Eur J Endocrinol. 1994 Sep;131(3):235-7. doi: 10.1530/eje.0.1310235.
Forty-nine acromegalics and 57 controls matched for age and sex underwent colonoscopy. The control group consisted of patients investigated because of atypical abdominal complaints compatible with irritable bowel syndrome or constipation. The exclusion criteria for both groups included: age over 75 years, previous colonic polyps or cancer, previous colonic surgery, rectal blood loss, anemia, previous abdominal radiation, sigmoidoscopy, colonoscopy or barium enema performed for any indication within 3 years prior to the present study. Colonoscopy was successful in reaching the cecum in 72 and 77% of the controls and acromegalics, respectively (p = NS). Eleven (22%) of 49 acromegalics had biopsy-proven colonic adenomas versus only five (9%) of the control group (p < or = 0.05). Multiple adenomas were found in three of the 11 acromegalics and in none of the controls. In five of these 11 patients and in only one of the controls, at least one adenoma was located in the right colon. In addition, acromegalics tended to have larger adenomas. The group of acromegalics with and without adenomas did not differ significantly in age or duration of active disease. In conclusion, the present study shows that acromegalic patients have an increased risk of developing colonic adenomas.
49例肢端肥大症患者和57例年龄及性别匹配的对照者接受了结肠镜检查。对照组由因符合肠易激综合征或便秘的非典型腹部症状而接受检查的患者组成。两组的排除标准包括：年龄超过75岁、既往有结肠息肉或癌症、既往有结肠手术史、直肠失血、贫血、既往腹部放疗史、在本研究前3年内因任何指征进行过乙状结肠镜检查、结肠镜检查或钡剂灌肠。结肠镜检查分别在72%的对照者和77%的肢端肥大症患者中成功抵达盲肠（p = 无显著性差异）。49例肢端肥大症患者中有11例（22%）经活检证实有结肠腺瘤，而对照组仅5例（9%）（p≤0.05）。11例肢端肥大症患者中有3例发现多发腺瘤，对照组无一例。在这11例患者中的5例以及对照组的仅1例中，至少有一个腺瘤位于右结肠。此外，肢端肥大症患者的腺瘤往往更大。有腺瘤和无腺瘤的肢端肥大症患者组在年龄或活动期疾病持续时间方面无显著差异。总之，本研究表明肢端肥大症患者发生结肠腺瘤的风险增加。
