Miller J S, Verfaillie C, McGlave P
Department of Medicine, University of Minnesota Medical School, Minneapolis 55455.
J Hematother. 1994 Spring;3(1):71-4. doi: 10.1089/scd.1.1994.3.71.
Ex vivo depletion of lymphocytes has been used to decrease the incidence of acute graft-versus-host disease following the allogeneic bone marrow transplantation. Many depletion techniques also remove natural killer (NK) cells that may mediate a beneficial graft-versus-leukemia effect. In this paper we review our studies on ex vivo expansion and activation of NK cells for use in the therapy of chronic myelogenous leukemia.
淋巴细胞的体外清除已被用于降低异基因骨髓移植后急性移植物抗宿主病的发生率。许多清除技术也会去除可能介导有益的移植物抗白血病效应的自然杀伤（NK）细胞。在本文中，我们回顾了我们关于用于慢性粒细胞白血病治疗的NK细胞体外扩增和激活的研究。
