Mossakowski M J, Wrzołkowa T, Tukaj C, Gadamski R
Department of Neuropathology, Medical Research Centre, Polish Academy of Sciences, Warsaw.
Folia Neuropathol. 1994;32(1):1-7.
Comparative morphometric analysis of terminal vascularization (vessels with a diameter lower than 12.5 microns) in the ischemia-sensitive sector CA1 and the ischemia-resistant sector CA3 of Ammon's horn in Mongolian gerbils was performed. Basing on numerous computer-counted parameters characterizing the terminal vascular network in both hippocampal sectors and its relationship to the surrounding tissue, it was shown that a number of capillary vessels, their average diameter, and exchange and flow surfaces were to a statistically significant degree lower in the pyramidal layer of the CA1 sector as compared with those in CA3 sector. The number of pyramidal neurons in the pyramidal layer, counted per surface unit was in sector CA1 higher than in sector CA3. The obtained data indicate clearly an angioarchitectonically dependent lower microvascular capacity of sector CA1. However, these differences do not indicate per se a leading role of the vascular factor in the pathomechanism of selective vulnerability to ischemia. They may be a factor facilitating neuronal damage evoked by the excitotoxic action of glutamate, observed in CA1 sector as a result of forebrain ischemia.
对蒙古沙鼠海马角的缺血敏感区CA1和缺血耐受区CA3的终末血管化（直径小于12.5微米的血管）进行了比较形态计量分析。基于大量通过计算机计数得出的参数，这些参数表征了两个海马区的终末血管网络及其与周围组织的关系，结果显示，与CA3区相比，CA1区锥体细胞层的一些毛细血管数量、它们的平均直径以及交换和流动表面在统计学上有显著降低。每单位表面计数的锥体细胞层中锥体细胞的数量在CA1区高于CA3区。所获得的数据清楚地表明CA1区的微血管容量在血管构筑学上较低。然而，这些差异本身并不表明血管因素在对缺血选择性易损性的发病机制中起主导作用。它们可能是促进谷氨酸兴奋性毒性作用诱发的神经元损伤的一个因素，在CA1区因前脑缺血而观察到这种作用。
