Mierzewska H, Schmidt-Sidor B, Kuchna I, Dambska M, Cukier K, Retka W
Department of Neuropathology, Medical School, Warsaw.
Folia Neuropathol. 1994;32(2):87-90.
A rare type of cellular reaction in the brain stem of two infants with cardiac arrest encephalopathy is presented. After cardiac arrest both newborns were resuscitated and put on artificial ventilation. Their survival time amounted to 16 and 18 days, respectively, in a deep coma with areflexia. At the postmortem examination a widespread hemispheric necrosis of the gray and white matter was observed as well as symmetrical necrosis of the tegmental part of the brain stem extending from the midbrain up to medulla. Striking proliferation of blood vessels and large number of multinucleated giant cells originating from monocyte/macrophage lineage was found in the areas of the brain stem necrosis. No evidence of inflammatory process was found. It seems that giant cells appeared as local reaction on disintegration of maturing structures.
本文报道了两例心脏骤停性脑病婴儿脑干中一种罕见的细胞反应类型。心脏骤停后，两名新生儿均被复苏并接受人工通气。他们分别在深度昏迷且无反射的状态下存活了16天和18天。尸检时，观察到大脑半球广泛的灰质和白质坏死，以及从中脑延伸至延髓的脑干被盖部对称性坏死。在脑干坏死区域发现了明显的血管增生以及大量源自单核细胞/巨噬细胞谱系的多核巨细胞。未发现炎症过程的证据。似乎巨细胞是成熟结构崩解时的局部反应。
