Mulvany M J
Institute of Pharmacology, University of Aarhus, Denmark.
Curr Opin Nephrol Hypertens. 1993 Jan;2(1):77-81. doi: 10.1097/00041552-199301000-00012.
It is well established that essential hypertension is associated with alterations in the structure of the resistance vasculature, such that the ratio of the media thickness to the lumen diameter (media-to-lumen ratio) is increased. Although these abnormalities are commonly thought to be due to vascular growth, they could be due to a rearrangement of a normal amount of material around a smaller lumen, a process known as remodeling. This paper reviews evidence for the relative contributions of growth and remodeling regarding subcutaneous resistance arteries taken from patients with essential hypertension. The available evidence suggests that the increased media-to-lumen ratio is due more to remodeling than to growth. This finding raises the possibility that vascular growth may not play a dominant role in the etiology of essential hypertension.
众所周知，原发性高血压与阻力血管结构的改变有关，即中膜厚度与管腔直径之比（中膜与管腔比）增加。尽管这些异常通常被认为是由于血管生长所致，但它们也可能是由于正常数量的物质围绕较小的管腔重新排列，这一过程称为重塑。本文综述了原发性高血压患者皮下阻力动脉生长和重塑相对贡献的证据。现有证据表明，中膜与管腔比增加更多是由于重塑而非生长。这一发现增加了血管生长可能在原发性高血压病因中不占主导地位的可能性。
