N-（氨基烷基）-4-乙酰基-3,5-二甲基吡咯-2-甲酰胺盐酸盐的合成与性质
Synthesis and properties of N-(aminoalkyl)-4-acetyl-3,5-dimethylpyrrole-2-carboxamides hydrochlorides.
作者信息
Bielawski K, Bołtryk J, Bartulewicz D, Krajewska D, Rózański A
机构信息
Department of Organic Chemistry, Medical University Białystok.
出版信息
Ann Med Univ Bialyst Pol. 1993;38(1):86-92.
PMID:7922492
Abstract
A series of N-(aminoalkyl)-4-acetyl-3,5-dimethylpyrrole-2-carboxamides hydrochlorides have been prepared and evaluated as cytostatic agents. General procedures were developed for constructing aminoalkyl chains on the 4-acetylpyrrole-2-carboxylic acid nuclei, utilizing 2-pyridone. The results of the preliminary biological activity have been mentioned.
摘要
已制备了一系列N-（氨基烷基）-4-乙酰基-3,5-二甲基吡咯-2-甲酰胺盐酸盐，并将其作为细胞生长抑制剂进行了评估。利用2-吡啶酮，开发了在4-乙酰基吡咯-2-羧酸核上构建氨基烷基链的通用方法。文中提到了初步生物活性的结果。
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