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[智力发育迟缓病因的流行病学研究]

[An epidemiological study on etiology of mental retardation].

作者信息

Zou Q H, Lei Z W, Zhang Z X

机构信息

Department of Pediatrics, First Hospital, Beijing Medical University.

出版信息

Zhonghua Yi Xue Za Zhi. 1994 Mar;74(3):134-7, 189.

PMID:7922745
Abstract

A cross-sectional epidemiological study was conducted to assess the prevalence and etiology of mental retardation (MR) among children under 14 years of age. The definition of MR and the criteria for diagnosis were adopted from WHO (1985). The IQ/DQ was evaluated with standardized psychological tests. The etiology of MR was specified by medical, genetic and psychosocial studies. A total of 862 retarded children were found among 85,170 surveyed. The overall adjusted prevalence rate was 1.20%. The percentage of mild, moderate, severe and profound MR was 60.6%, 22.7%, 9.6%, and 7.1%, respectively. Specific causes were found in 673 cases (79.1%). The etiology was unknown in 21.9% children. Timing of the causes showed prenatal in 34% perinatal 11.9%, postnatal 33%. Biomedical causes consisted of 89.6% and sociocultural factors, 10.4%. Among the prenatal factors, genetic diseases ranked first and manifested as chromosomal abnormalities and inborn errors of metabolism. Among the postnatal causes, sequelae of CNS infections and other forms of acquired brain insult were most important. Most children of socio-cultural MR were at school age and of the mild category. Our results show that most MR cases are preventable.

摘要

开展了一项横断面流行病学研究,以评估14岁以下儿童智力发育迟缓(MR)的患病率和病因。MR的定义和诊断标准采用世界卫生组织(1985年)的标准。通过标准化心理测试评估智商/发育商。通过医学、遗传学和社会心理研究确定MR的病因。在85170名接受调查的儿童中,共发现862名发育迟缓儿童。总体校正患病率为1.20%。轻度、中度、重度和极重度MR的比例分别为60.6%、22.7%、9.6%和7.1%。673例(79.1%)发现了具体病因。21.9%的儿童病因不明。病因发生时间显示,产前占34%,围产期占11.9%,产后占33%。生物医学原因占89.6%,社会文化因素占10.4%。产前因素中,遗传疾病位居首位,表现为染色体异常和先天性代谢缺陷。产后病因中,中枢神经系统感染后遗症和其他形式的获得性脑损伤最为重要。大多数社会文化性MR儿童为学龄期且属于轻度类型。我们的结果表明,大多数MR病例是可预防的。

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