[Influences of lipid peroxidative injury to endothelial cells on adherence and migration of monocyte].

The influences of lipid peroxidative injury to endothelial cells (EC) on adherence to EC and migration into subendothelial space of human monocytes were studied by using a modified vascular endothelial model in vitro. Lipid peroxidative injury to cultured human umbilical vein EC was initiated by treating the EC with diamide. The results showed that injury to EC could enhance adherence to EC and migration into subendothelial space of monocytes. Monocytes mainly adhered to the intercellular space and surface of injured EC. In the area of EC denudation, the number of monocytes which migrate into the subendothelial space was more than that in the area without denudation. These results suggested that enhanced adherence to EC and migration into subendothelial space of monocytes caused by lipid peroxidative injury to EC may play an important role in atherogenesis.