Kabasawa H, Matsubara M, Kamimoto K, Hibino H, Banno T, Nagai H
Department of Neurology, Nagoya City Rehabilitation and Sports Center, Japan.
Clin Ther. 1994 May-Jun;16(3):471-82.
The effects of bifemelane hydrochloride on aphasia and on cerebral circulation and metabolism were studied using positron emission tomography (PET) in 10 aphasic patients with cerebrovascular disease. After the first PET scan, bifemelane was administered orally three times in a daily dose of 150 mg. Aphasic features, such as fluency, auditory comprehension, object naming, and repetition, were evaluated by using the Western Aphasia Battery (Japanese edition) before and at least 2 months after bifemelane treatment. Simultaneous with the evaluation of aphasia, the PET scans were performed by using the steady-state method with 15O gases inhalation. All aphasic features, except fluency, improved significantly after bifemelane treatment. Regional cerebral blood flow (rCBF) and the cerebral metabolic rate for oxygen (CMRO2) were increased at every brain region of interest, and the oxygen extraction fraction was decreased. Both rCBF and CMRO2 were significantly increased on the left inferior frontal gyrus, superior temporal gyrus, white matter of the parietal lobe, and insula. These results suggest that bifemelane improves both cerebral oxygen metabolism and cerebral circulation and contributes to the improvement of aphasia caused by cerebrovascular disease.
采用正电子发射断层扫描（PET）技术，对10例脑血管病所致失语患者进行研究，观察盐酸比芬美兰对失语症以及脑循环和代谢的影响。首次PET扫描后，口服盐酸比芬美兰，每日3次，每次50mg。在比芬美兰治疗前及治疗至少2个月后，使用西方失语成套测验（日本版）对失语特征，如流畅性、听觉理解、物体命名及复述等进行评估。在评估失语的同时，采用吸入15O气体的稳态法进行PET扫描。比芬美兰治疗后，除流畅性外的所有失语特征均有显著改善。各感兴趣脑区的局部脑血流量（rCBF）和脑氧代谢率（CMRO2）均升高，氧摄取分数降低。左侧额下回、颞上回、顶叶白质和脑岛的rCBF和CMRO2均显著升高。这些结果表明，比芬美兰可改善脑氧代谢和脑循环，有助于改善脑血管病所致的失语症。
