Klein M, Kaminsky P, Deibener J, Cocciale M P, Duc M
Service de Médecine J, Centre Hospitalier Universitaire de Nancy, Hôpitaux de Brabois, Vandoeuvre-lès Nancy, France.
Chest. 1994 Oct;106(4):1304-5. doi: 10.1378/chest.106.4.1304.
A diagnosis of sarcoidosis was evoked in a 61-year-old man on clinical and histologic bases. Nevertheless, a bile duct carcinoma was disclosed in association with the discovery of generalized sarcoid-like granulomas. This is only the third time that such an association has been described. HLA-B8, DR3, and DRw52 antigens were found, suggesting that altered immunologic mechanisms could play a role in the pathogenesis of this sarcoid-like reaction.
一名61岁男性经临床和组织学检查被诊断为结节病。然而，在发现全身类似结节病的肉芽肿时，发现了胆管癌。这是此类关联仅第三次被描述。发现了HLA - B8、DR3和DRw52抗原，提示免疫机制改变可能在这种类似结节病反应的发病机制中起作用。
