不同类型鼻咽上皮细胞核DNA含量的变化
Changes of nuclear DNA content in different types of nasopharyngeal epithelium.
作者信息
Zhao S P, Tao Z D, Xiao J Y, Xiao P T, Peng Y Y
机构信息
Department of Otolaryngology, Xiang Ya Hospital, Hunan Medical University, Changsha.
出版信息
Chin Med J (Engl). 1994 May;107(5):371-4.
The unclear DNA content was measured with flow cytometry (FCM) in 167 specimens of normal nasopharyngeal epithelium (NE), adjacent tissue to carcinoma (ATC) and nasopharyngeal carcinoma (NPC). All 20 patients with NE showed diploid, whereas 38 (38%) of 101 patients with NPC, 7 (58%) of 12 patients with recurrent NPC, 6 (30%) of 20 patients with ATC and 2 (33%) of 6 patients with NE, positive to EBVCA-IgA test, showed nondiploid. In addition, cellular proliferation index (PI) of diploid NPC and diploid ATC, though differed nonsignificantly, was significantly increased as compared with that of NE (P < 0.01). The rate of cervical metastasis in nondiploid NPC was significantly higher than that in diploid NPC (P < 0.025).
应用流式细胞术（FCM）检测167例正常鼻咽上皮（NE）、癌旁组织（ATC）及鼻咽癌（NPC）标本的DNA含量。20例NE患者均显示为二倍体，而101例NPC患者中有38例（38%）、12例复发性NPC患者中有7例（58%）、20例ATC患者中有6例（30%）以及6例EBVCA-IgA检测阳性的NE患者中有2例（33%）显示为非二倍体。此外，二倍体NPC和二倍体ATC的细胞增殖指数（PI）虽差异无统计学意义，但与NE相比显著升高（P<0.01）。非二倍体NPC的颈部转移率显著高于二倍体NPC（P<0.025）。
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