Park Y S, Park S, Park K S, Kim S Y, Lee H K, Koh C S, Min H K, Kim J Q
Department of Internal Medicine, Seoul National University College of Medicine, Korea.
Diabetes Res Clin Pract. 1994 May;24(1):25-31. doi: 10.1016/0168-8227(94)90082-5.
To determine whether previously reported abnormalities in fibrinolytic activity and plasma lipoprotein (a) levels could reflect obesity rather than diabetes per se, plasma concentrations of tissue-type plasminogen activator (t-PA), type 1 plasminogen activator inhibitor (PAI-1), and lipoprotein (a) (Lp (a)) were investigated in sixty-four type 2 diabetic patients (56.1 +/- 9.5 years; body mass index, 24.6 +/- 3.3 kg/m2) and thirty-two control subjects (57.9 +/- 8.9 years; body mass index, 24.6 +/- 3.4 kg/m2). Both the plasma t-PA and PAI-1 antigen levels were similar between the diabetic group (10.6 +/- 3.8 ng/ml; 27.7 +/- 11.6 ng/ml) and the control group (12.2 +/- 3.5 ng/ml; 27.7 +/- 9.6 ng/ml). The PAI-1 levels were evenly distributed from 5.93 to 52.7 ng/ml in diabetic patients. The difference of Lp (a) levels between the two groups was negligible (the diabetic group, median 11 mg/dl (range 0-72 mg/dl); the control group, median 13 mg/dl (range 0-55 mg/dl)). Significant correlations between PAI-1 levels and body mass index (BMI) were observed in both groups. In the diabetic group, PAI-1 levels also correlated with fasting C-peptide levels (r = 0.54, P < 0.01) and serum triglyceride levels (r = 0.28, P < 0.05). However, we could not find a significant association between either t-PA or PAI-1 levels and Lp (a) levels in the diabetic and control groups.(ABSTRACT TRUNCATED AT 250 WORDS)
为了确定先前报道的纤溶活性和血浆脂蛋白(a)水平异常是反映肥胖而非糖尿病本身，我们对64例2型糖尿病患者（年龄56.1±9.5岁；体重指数，24.6±3.3kg/m²）和32例对照者（年龄57.9±8.9岁；体重指数，24.6±3.4kg/m²）的组织型纤溶酶原激活物(t-PA)、1型纤溶酶原激活物抑制剂(PAI-1)和脂蛋白(a)[Lp(a)]的血浆浓度进行了研究。糖尿病组(10.6±3.8ng/ml；27.7±11.6ng/ml)和对照组(12.2±3.5ng/ml；27.7±9.6ng/ml)的血浆t-PA和PAI-1抗原水平相似。糖尿病患者的PAI-1水平在5.93至52.7ng/ml之间均匀分布。两组之间Lp(a)水平的差异可忽略不计（糖尿病组，中位数11mg/dl(范围0-72mg/dl)；对照组，中位数13mg/dl(范围0-55mg/dl)）。两组均观察到PAI-1水平与体重指数(BMI)之间存在显著相关性。在糖尿病组中，PAI-1水平还与空腹C肽水平(r=0.54，P<0.01)和血清甘油三酯水平(r=0.28，P<0.05)相关。然而，我们未在糖尿病组和对照组中发现t-PA或PAI-1水平与Lp(a)水平之间存在显著关联。（摘要截短至250字）
