Thabaut A, Meyran M, Sofer L, Morand A, Labia R
Biology Laboratory, Hospital Bégin, Saint-Mandé.
Drugs Exp Clin Res. 1994;20(2):49-54.
The authors analysed the antibacterial activity of ceftibuten, cefotaxime, ceftazidime and aztreonam against Klebsiella pneumoniae strains, including those which produced novel extended-spectrum beta-lactamases. These molecules were also tested for their susceptibility to cell-free extracts of the corresponding beta-lactamases. Both approaches showed that ceftibuten was not hydrolysed by the CTX-1/TEM-3, SHV-2 and SHV-3 beta-lactamases, while cefotaxime, ceftazidime and aztreonam were hydrolysed. Nevertheless all compounds were substrates for the SHV-4 and SHV-5 beta-lactamases, and the organisms which produced these beta-lactamases showed increased MICs.
作者分析了头孢布烯、头孢噻肟、头孢他啶和氨曲南对肺炎克雷伯菌菌株的抗菌活性，包括那些产生新型超广谱β-内酰胺酶的菌株。还测试了这些分子对相应β-内酰胺酶无细胞提取物的敏感性。两种方法均表明，CTX-1/TEM-3、SHV-2和SHV-3β-内酰胺酶不会水解头孢布烯，而头孢噻肟、头孢他啶和氨曲南会被水解。然而，所有化合物都是SHV-4和SHV-5β-内酰胺酶的底物，产生这些β-内酰胺酶的菌株显示出更高的最低抑菌浓度（MIC）。
