Miller R D, von Ehrenburg W
Department of Anesthesia, University of California, San Francisco.
Eur J Anaesthesiol Suppl. 1994;9:1-8.
The introduction of each new muscle relaxant has advanced anaesthetic practice by trying to meet some perceived deficiency in the existing therapeutic armamentarium. Anaesthesiologists need agents which are appropriate to the duration of surgery: they prefer agents which are not subject to drug interaction, have no effect on cardiovascular function, which do not depend significantly on renal excretion, which are easy to reverse, and which have a rapid onset of action. In certain circumstances one of these requirements becomes overridingly important. The latest new addition, rocuronium, fills the gap for an agent with rapid onset while lacking the potentially adverse features of suxamethonium, retaining a medium duration of action and meeting the other requirements set out above as well as any existing agent.
每一种新型肌肉松弛剂的引入都试图弥补现有治疗药物的某些不足之处，从而推动了麻醉实践的发展。麻醉医生需要适用于手术时长的药物：他们更倾向于那些不会发生药物相互作用、对心血管功能无影响、不太依赖肾脏排泄、易于逆转且起效迅速的药物。在某些情况下，这些要求中的某一项会变得极为重要。最新添加的药物罗库溴铵填补了快速起效药物的空白，同时没有琥珀胆碱的潜在不良特性，作用时长适中，并且满足上述其他要求以及现有任何药物所具备的条件。
