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ω-芋螺毒素GVIA和MVIIC对神经刺激诱导的豚鼠回肠和大鼠输精管收缩的不同作用。

Differential effects of omega-conotoxin GVIA and MVIIC on nerve stimulation induced contractions of guinea-pig ileum and rat vas deferens.

作者信息

Boot J R

机构信息

Eli Lilly & Co., Lilly Research Centre Ltd., Windlesham, Surrey, UK.

出版信息

Eur J Pharmacol. 1994 Jun 2;258(1-2):155-8. doi: 10.1016/0014-2999(94)90069-8.

DOI:10.1016/0014-2999(94)90069-8
PMID:7925595
Abstract

omega-Conotoxin GVIA and omega-conotoxin MVIIC caused similar concentration-dependent reductions of the electrically induced twitch responses of guinea-pig ileum. The inhibitory effects of omega-conotoxin GVIA were long-lasting whereas those to omega-conotoxin MVIIC were readily reversed. Preincubation with omega-conotoxin MVIIC prevented the irreversible inhibition of omega-conotoxin GVIA suggesting a common site of interaction. However, unlike omega-conotoxin GVIA which caused inhibition, omega-conotoxin MVIIC did not affect the electrically induced twitch responses of the rat vas deferens nor did it prevent the irreversible inhibition with omega-conotoxin GVIA. This study indicates the possible existence of different subtypes of the N-type voltage-dependent calcium channel.

摘要

ω-芋螺毒素GVIA和ω-芋螺毒素MVIIC对豚鼠回肠电诱发的抽搐反应产生了类似的浓度依赖性降低。ω-芋螺毒素GVIA的抑制作用是持久的，而对ω-芋螺毒素MVIIC的抑制作用则很容易逆转。用ω-芋螺毒素MVIIC预孵育可防止ω-芋螺毒素GVIA的不可逆抑制，提示存在共同的相互作用位点。然而，与引起抑制作用的ω-芋螺毒素GVIA不同，ω-芋螺毒素MVIIC对大鼠输精管的电诱发抽搐反应没有影响，也不能防止ω-芋螺毒素GVIA的不可逆抑制。本研究表明N型电压依赖性钙通道可能存在不同亚型。

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Differential effects of omega-conotoxin GVIA and MVIIC on nerve stimulation induced contractions of guinea-pig ileum and rat vas deferens.ω-芋螺毒素GVIA和MVIIC对神经刺激诱导的豚鼠回肠和大鼠输精管收缩的不同作用。
Eur J Pharmacol. 1994 Jun 2;258(1-2):155-8. doi: 10.1016/0014-2999(94)90069-8.
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Upregulation of L-type calcium channels in colonic inhibitory motoneurons of P/Q-type calcium channel-deficient mice.P/Q型钙通道缺陷小鼠结肠抑制性运动神经元中L型钙通道的上调
Am J Physiol Gastrointest Liver Physiol. 2016 Oct 1;311(4):G763-G774. doi: 10.1152/ajpgi.00263.2016. Epub 2016 Sep 1.
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Lack of effect of Z-butylidenephthalide on presynaptic N-type Ca²⁺ channels in isolated guinea-pig ileum.
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Naunyn Schmiedebergs Arch Pharmacol. 2010 Dec;382(5-6):419-32. doi: 10.1007/s00210-010-0556-z. Epub 2010 Sep 5.
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