两只实验用比格犬的角膜皮样瘤。

Corneal dermoid in two laboratory beagle dogs.

作者信息

Horikiri K, Ozaki K, Maeda H, Narama I

机构信息

Research Institute of Drug Safety, Setsunan University, Osaka, Japan.

出版信息

Jikken Dobutsu. 1994 Jul;43(3):417-20. doi: 10.1538/expanim1978.43.3_417.

DOI:10.1538/expanim1978.43.3_417

PMID:7925632

Abstract

Two male laboratory beagle dogs used in toxicity studies, one 7 months old and the other 9 months old, showed the evidence of corneal dermoid. Grossly, the dermoid was observed in both cases as hair growth from the cornea. In one case, the hairs had been removed from the cornea, but regrowth was observed about 70 days later. Histopathologically, melanocytes, melanin granules, hairs, hair bulbs, adipose tissue and sebaceous and sweat glands were observed in the corneal epithelium and propria. According to the information obtained from 4 breeders, the incidence of corneal dermoid was extremely rare in laboratory beagle dogs.

摘要

用于毒性研究的两只雄性实验比格犬，一只7个月大，另一只9个月大，出现了角膜皮样瘤的迹象。大体上，在这两个病例中均观察到皮样瘤表现为角膜上有毛发长出。在其中一个病例中，角膜上的毛发已被拔除，但约70天后观察到毛发再次生长。组织病理学检查发现，在角膜上皮和固有层中观察到黑素细胞、黑色素颗粒、毛发、毛球、脂肪组织以及皮脂腺和汗腺。根据从4位饲养员处获得的信息，实验比格犬中角膜皮样瘤的发生率极其罕见。