Helleday R, Sandström T, Stjernberg N
Dept of Pulmonary Medicine and Allergology, University Hospital of Northern Sweden, Umeå.
Eur Respir J. 1994 Jul;7(7):1213-20. doi: 10.1183/09031936.94.07071213.
We have previously reported on the bronchoalveolar inflammatory effects of the common air pollutant NO2 in nonsmokers. In this study, we have investigated these effects in tobacco smokers. Eight young nonbronchitic smokers and, as a reference group, eight healthy life-time nonsmokers were exposed to 3.5 ppm NO2 for 20 min. Bronchoalveolar lavage (BAL) was performed 3 weeks before and 24 h after exposure. The first recovered 20 ml was analysed separately and defined as the bronchial portion (BP), and the following fluid recovered as the bronchoalveolar portion (BAP). Before exposure, the smokers had significantly less CD3+ cells and more alveolar macrophages (AMs) in the BP and the BAP, as well as reduced AM phagocytosis in vitro compared to nonsmokers. After NO2 exposure, the smokers reacted with an increase of AMs and neutrophils in BAP. Nonsmokers reacted with an increase of neutrophils in BP, an increase of lymphocytes in BAP, and a tendency to reduced AM phagocytosis. In summary, young smokers and nonsmokers differed to some extent in their reactions to NO2 exposure. This is probably due to the pre-existing airway inflammation and compensatory mechanisms to oxidant stress in the smokers.
我们之前曾报道过常见空气污染物二氧化氮对不吸烟者支气管肺泡的炎症影响。在本研究中，我们调查了吸烟者的这些影响。八名年轻的非支气管性吸烟者以及作为参照组的八名终生不吸烟的健康者，暴露于3.5 ppm的二氧化氮中20分钟。在暴露前3周和暴露后24小时进行支气管肺泡灌洗（BAL）。首次回收的20 ml单独分析并定义为支气管部分（BP），随后回收的液体为支气管肺泡部分（BAP）。暴露前，与不吸烟者相比，吸烟者在BP和BAP中的CD3 +细胞显著减少，肺泡巨噬细胞（AM）更多，并且体外AM吞噬作用降低。二氧化氮暴露后，吸烟者BAP中的AM和中性粒细胞增加。不吸烟者BP中的中性粒细胞增加，BAP中的淋巴细胞增加，并且AM吞噬作用有降低的趋势。总之，年轻吸烟者和不吸烟者对二氧化氮暴露的反应在一定程度上有所不同。这可能是由于吸烟者预先存在的气道炎症和对氧化应激的代偿机制。
