孕激素对接受序贯激素替代疗法的绝经后妇女子宫动脉搏动指数的时间效应。
The temporal effect of progestogen on uterine artery pulsatility index in postmenopausal women receiving sequential hormone replacement therapy.
作者信息
Marsh M S, Bourne T H, Whitehead M I, Collins W P, Campbell S
机构信息
Academic Department of Obstetrics and Gynaecology, King's College School of Medicine and Dentistry, London, United Kingdom.
出版信息
Fertil Steril. 1994 Oct;62(4):771-4. doi: 10.1016/s0015-0282(16)57002-2.
OBJECTIVE
To determine the time relationship between the ingestion of progestogen during sequential hormone replacement therapy (HRT) and impedance to blood flow in the uterine arteries.
DESIGN
Nine postmenopausal women who had already received HRT for at least 6 months were treated with either transdermal 17 beta-E2, 0.1 mg/d, or conjugated equine estrogens (Es), 1.25 mg/d, to which norethindrone, 0.7 mg/d, was added for 12 days in a single 28-day cycle of therapy. Transvaginal ultrasonography with color flow imaging was used to measure the pulsatility index (PI) in the uterine arteries every 3 to 5 days over one 28-day treatment cycle.
RESULTS
The ingestion of norethindrone increased the mean uterine artery PI by 30% (SE 16.4%). The PI fell significantly within 4 days of ceasing norethindrone.
CONCLUSION
Progestogen addition in sequential HRT causes changes in the uterine arterial tone, but the effect subsides within 4 days of progestogen withdrawal.
目的
确定序贯激素替代疗法（HRT）期间孕激素摄入与子宫动脉血流阻抗之间的时间关系。
设计
9名已接受HRT至少6个月的绝经后妇女，在一个28天的治疗周期中，接受以下治疗：每天经皮给予17β-雌二醇0.1mg，或每天给予结合马雌激素（Es）1.25mg，并在其中12天每天加用炔诺酮0.7mg。在一个28天的治疗周期内，每3至5天使用经阴道超声彩色血流成像测量子宫动脉的搏动指数（PI）。
结果
摄入炔诺酮使子宫动脉平均PI增加30%（标准误16.4%）。停止服用炔诺酮后4天内，PI显著下降。
结论
序贯HRT中添加孕激素会导致子宫动脉张力改变，但在停用孕激素后4天内这种效应会消退。
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