Rabinovitz M, Demetris A J
Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania.
Gastroenterology. 1994 Oct;107(4):1162-4. doi: 10.1016/0016-5085(94)90242-9.
Whereas giant cell hepatitis (GCH) is a common diagnosis made in neonates, it is rare in the adult population. The diagnosis of GCH is based on the presence of giant cell transformation of hepatocytes. It is commonly associated with either viral hepatitis or autoimmune disorders. A patient with GCH who had anti-M2 mitochondrial antibodies is described. This combination, which has not been previously reported, underscores the association of GCH with autoimmune disorders and stresses the importance of corticosteroids as an empirical initial therapy.
巨细胞性肝炎（GCH）在新生儿中是常见诊断，但在成人中罕见。GCH的诊断基于肝细胞的巨细胞转化。它通常与病毒性肝炎或自身免疫性疾病相关。本文描述了一名患有抗M2线粒体抗体的GCH患者。这种此前未被报道过的组合，凸显了GCH与自身免疫性疾病的关联，并强调了皮质类固醇作为经验性初始治疗的重要性。
