Satoh K, Ohtani H, Shimosegawa T, Koizumi M, Sawai T, Toyota T
Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Gastroenterology. 1994 Nov;107(5):1488-95. doi: 10.1016/0016-5085(94)90554-1.
BACKGROUND/AIMS: Basement membrane disruption is a characteristic of invasive carcinoma. Gelatinases (also called type IV collagenases) that degrade type IV collagen are believed to play an important role in tumor invasion and metastasis. Intraductal neoplasm (IDN) of the pancreas is a unique tumor that grows intraductally with an infrequent stromal invasion. However, in IDN, basement membrane anomaly and gelatinase expression have not been clarified. The aim of this study was to examine the relationships between basement membrane disruption and the expression of gelatinase A in relation to the biological behavior of IDN or pancreatic duct cell carcinoma (DCC).
Disruption of basement membrane and expression of gelatinase A were immunohistochemically investigated in 14 cases of IDN and 16 cases of DCC.
Basement membrane was intact in all cases of IDN, whereas focal to severe disruption was observed in DCC. Stromal expression of gelatinase A was higher in DCC than in IDN, and the intensity of expression was related to the degree of disruption of the basement membrane in DCC.
Stromal expression of gelatinase A and disruption of basement membrane, common characteristics of invasive cancer, were not prominent in IDN. This may be related to the benign biological behavior of IDN.
背景/目的：基底膜破坏是浸润性癌的一个特征。降解IV型胶原的明胶酶（也称为IV型胶原酶）被认为在肿瘤侵袭和转移中起重要作用。胰腺导管内肿瘤（IDN）是一种独特的肿瘤，它在导管内生长，很少发生间质浸润。然而，在IDN中，基底膜异常和明胶酶表达尚未明确。本研究的目的是探讨基底膜破坏与明胶酶A表达之间的关系，以及它们与IDN或胰腺导管细胞癌（DCC）生物学行为的关系。
对14例IDN和16例DCC进行免疫组织化学研究，观察基底膜破坏情况和明胶酶A的表达。
所有IDN病例的基底膜均完整，而DCC中观察到局灶性至严重破坏。DCC中明胶酶A的间质表达高于IDN，且表达强度与DCC中基底膜的破坏程度相关。
明胶酶A的间质表达和基底膜破坏是浸润性癌的共同特征，在IDN中并不突出。这可能与IDN的良性生物学行为有关。
