疾病中人类胃蛋白酶的亚部位研究。
Subsite study of human pepsin in disease.
作者信息
Balbaa M, Hamed E A, el-Ashwah A, Salem O, Shamss-Eldin A
机构信息
Department of Biochemistry, Faculty of Science, Alexandria University, Egypt.
出版信息
Indian J Biochem Biophys. 1994 Apr;31(2):136-7.
PMID:7927435
Abstract
The synthetic peptides AC-Glu-Phe-Phe (NO2)-Arg-amide (peptide VP) and AC-Ile-Glu-Phe-Phe (NO2)-Arg-amide (peptide VIP) are more readily hydrolyzed by human pepsin in gastric juice of patients of gastritis than those of duodenal ulcer and normal subjects. The kinetic parameters suggest that S3 subsite of the enzyme plays a role in the elevation of enzyme activity in gastric disease.
摘要
合成肽AC-谷氨酸-苯丙氨酸-苯丙氨酸（硝基）-精氨酸酰胺（肽VP）和AC-异亮氨酸-谷氨酸-苯丙氨酸-苯丙氨酸（硝基）-精氨酸酰胺（肽VIP）在胃炎患者胃液中比在十二指肠溃疡患者和正常受试者胃液中更容易被人胃蛋白酶水解。动力学参数表明，该酶的S3亚位点在胃部疾病中酶活性升高方面发挥作用。
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