蜕膜化诱导后大鼠子宫内膜中尿激酶型纤溶酶原激活剂的表达增强。
Enhanced expression of urokinase-type plasminogen activator in the rat endometrium following induction of decidualisation.
作者信息
Tarachand U, Pawse A R
机构信息
Radiation Biology and Biochemistry Division, Bhabha Atomic Research Centre, Bombay.
出版信息
Indian J Exp Biol. 1994 May;32(5):304-6.
Urokinase-type plasminogen activator(uPA) assayed in uteri of cycling and deciduoma bearing rats shows detectable levels of this enzyme in endometrium. Zymographic analysis confirms uPA of decidual tissue and, following artificial induction of decidualisation, uPA activity constantly increases in the decidualising endometrium reaching a peak on day 9 of pseudopregnancy. Endometrial uPA of nonpregnant rats does not show any significant change during estrous cycle. Results are discussed in relation to expression of this activator in endometrium of rats during morphogenesis of decidual cells.
在处于发情周期的大鼠子宫以及患有蜕膜瘤的大鼠子宫中检测尿激酶型纤溶酶原激活剂（uPA），结果显示子宫内膜中可检测到该酶。酶谱分析证实了蜕膜组织中存在uPA，并且在人工诱导蜕膜化后，正在蜕膜化的子宫内膜中uPA活性持续增加，在假孕第9天达到峰值。未孕大鼠的子宫内膜uPA在发情周期中未显示出任何显著变化。本文结合该激活剂在蜕膜细胞形态发生过程中在大鼠子宫内膜中的表达情况对结果进行了讨论。
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