Krishnamurti L, Charan V D, Desai N, Pati H, Choudhry V P
Department of Hematology, All India Institute of Medical Sciences, New Delhi.
Indian J Pediatr. 1994 Mar-Apr;61(2):179-82. doi: 10.1007/BF02843613.
Anti-D was evaluated in 8 RhD positive patients (6 males, 2 females) aged 2-21 years (mean 10 years) with Idiopathic Thrombocytopenic Purpura (ITP). Five patients with chronic ITP and 3 patients with acute ITP were administered Anti-D in the dosage of 50 micrograms/kg intramuscularly (IM) for 3 consecutive days. One patient of chronic ITP received two courses of Anti-D. Patients were followed up for 7 to 16 months (mean 9 months). All three cases of acute ITP had a complete response and are in remission between 3 to 12 months of follow up. Two of five cases of chronic ITP had a partial response. Rise in platelet count was observed within 72-124 hours, and duration of response varied between 10 to 15 days. None of these patients had any significant side effects of anti-D immunoglobulin therapy. Intramuscular administration of Anti-D is safe, effective and low cost alternative to IVIgG in the treatment of acute ITP.
对8例年龄在2至21岁（平均10岁）的特发性血小板减少性紫癜（ITP）RhD阳性患者（6例男性，2例女性）进行了抗-D评估。5例慢性ITP患者和3例急性ITP患者接受了剂量为50微克/千克的抗-D肌肉注射，连续3天。1例慢性ITP患者接受了两个疗程的抗-D治疗。对患者进行了7至16个月（平均9个月）的随访。所有3例急性ITP患者均有完全缓解，在随访的3至12个月内处于缓解状态。5例慢性ITP患者中有2例有部分缓解。在72至124小时内观察到血小板计数升高，缓解持续时间在10至15天之间。这些患者均未出现抗-D免疫球蛋白治疗的任何显著副作用。在急性ITP的治疗中，肌肉注射抗-D是一种安全、有效且低成本的替代静脉注射免疫球蛋白的方法。
