Gopinathan U, Agrawal V, Sharma S, Rao G N
Sri Devchand Nagardas Jhaveri Microbiology Centre, Hyderabad.
Indian J Ophthalmol. 1994 Jun;42(2):71-4.
Gentamicin is the most widely used antibiotic in the decontamination of donor cornea for penetrating keratoplasty. However, the incidence of resistance to gentamicin is on the rise. Bacterial isolates from 178 donor corneal rims were studied for gentamicin sensitivity. The overall rate of gentamicin resistance was 63.4%. At 86.2% the Pseudomonas. species had the highest rate of resistance, followed by Streptococci at 84.6%. The high rate of gentamicin resistance encountered by us and others suggest that either addition of a second antibiotic to corneal storage media or replacement of gentamicin by an antibiotic with a broader spectrum of activity may help reduce the risk of endophthalmitis following penetrating keratoplasty.
庆大霉素是穿透性角膜移植术中用于供体角膜去污的最常用抗生素。然而，对庆大霉素的耐药率正在上升。对178个供体角膜缘的细菌分离株进行了庆大霉素敏感性研究。庆大霉素的总体耐药率为63.4%。假单胞菌属的耐药率最高，为86.2%，其次是链球菌，为84.6%。我们和其他人遇到的庆大霉素高耐药率表明，要么在角膜储存介质中添加第二种抗生素，要么用具有更广泛活性谱的抗生素替代庆大霉素，可能有助于降低穿透性角膜移植术后眼内炎的风险。
