Nahrendorf G, Carol W, Klinger G
Zentralbl Gynakol. 1978;100(10):632-7.
The problem of whether or not oral contraceptives affect the psychic function of the female is still controversal. The purpose of the present investigation was to study the occurrence of psychic and sexual effects in women taking either Ovosiston (mestranol 0,08 mg + chlormadinone acetate 2, 0 mg) or Non-Ovlon (ethinylestradiol 0,05 mg + norethisterone acetate 1,0 mg). 186 somatically healthy women were subject to two interviews, immediately before the start of therapy and six months after it. Most of the patients recorded distinctly alterations of their mood, their initiative, their elemental desires such as appetite, sleep, need of warmth, and their sexual behaviour. 73 of them noted a change in their emotional pattern, which was positive in 34 and negative in 39 cases. 99 women reported changes in their elemental desires. 136 patients exhibited alterations of their sexual behaviour, which were assessed as an improvement or impairment in 108 and 28 cases, respectively. There is a statistically significant correlation between the impairment of sexual function and the incidence of other untoward side effects. On the other hand, negative suggestion by poor experience of other women on by the influence of mass media seems to play a minor role in producing changes of sexual behaviour. There is, however, a clearcut relationship between negative suggestion and the incidence of unfavourable emotional alterations. The findings are discussed with reference to their clinical significance.
口服避孕药是否会影响女性的心理功能这一问题仍存在争议。本研究的目的是探讨服用奥沃西斯顿（炔雌醇甲醚0.08毫克+醋酸氯地孕酮2.0毫克）或诺孕丸（炔雌醇0.05毫克+醋酸炔诺酮1.0毫克）的女性出现心理和性方面影响的情况。186名身体健康的女性在治疗开始前和治疗六个月后分别接受了两次访谈。大多数患者记录到自己的情绪、主动性、诸如食欲、睡眠、对温暖的需求等基本欲望以及性行为都有明显变化。其中73人注意到自己情绪模式有变化，34例为积极变化，39例为消极变化。99名女性报告了基本欲望的变化。136名患者表现出性行为的改变，其中108例被评估为改善，28例被评估为受损。性功能受损与其他不良副作用的发生率之间存在统计学上的显著相关性。另一方面，其他女性的不良经历或大众媒体的影响所产生的负面暗示，在导致性行为改变方面似乎作用较小。然而，负面暗示与不良情绪改变的发生率之间存在明显的关联。文中结合这些发现的临床意义进行了讨论。
