Maruyama Y, Ezzell G, Porter A T
Department of Radiation Oncology, Gershenson Radiation Oncology Center, Wayne State University, Detroit, MI 48201.
Int J Radiat Oncol Biol Phys. 1994 Sep 30;30(2):473-6. doi: 10.1016/0360-3016(94)90030-2.
To design an afterloading vaginal cylinder application appropriate to treat the vault with high dose rate (HDR) brachytherapy after prior total abdominal hysterectomy.
A vaginal cylinder was designed and built using nylon and source loading channels positioned for source movement for HDR vault and vaginal brachytherapy. The channels are positioned to treat a broader isodose surface and to avoid the "end" effects of linear source brachytherapy. The central channel allows an applicator tube to be advanced beyond the end of the cylinder to treat a "tented" vault or a cervical stump (or uterus). Additional peripheral sources can be added to allow vaginal wall plaque therapy.
The application allows vault, vault plus proximal vagina, or vault plus entire vagina therapy using HDR. The isodose surface treated is controlled by source positioning and dwell times.
The HDR cylinder has wide potential usability for uterus or cervix therapy as both low stage and operable endometrial carcinomas are now usually treated by surgery.
设计一种后装阴道施源器，适用于在先前全腹子宫切除术后采用高剂量率（HDR）近距离放射治疗阴道穹窿。
使用尼龙设计并制作了一个阴道施源器，其源加载通道的位置便于高剂量率阴道穹窿和阴道近距离放射治疗时源的移动。这些通道的位置可用于治疗更宽的等剂量面，并避免线性源近距离放射治疗的“末端”效应。中央通道允许施源管延伸至施源器末端之外，以治疗“帐篷状”阴道穹窿或宫颈残端（或子宫）。可添加额外的周边源以进行阴道壁敷贴治疗。
该施源器可使用高剂量率进行阴道穹窿、阴道穹窿加近端阴道或阴道穹窿加整个阴道的治疗。所治疗的等剂量面由源的位置和驻留时间控制。
由于现在低分期和可手术的子宫内膜癌通常通过手术治疗，高剂量率施源器在子宫或宫颈治疗方面具有广泛的潜在实用性。
