Dinning W J
Postgrad Med J. 1976 Oct;52(612):634-8. doi: 10.1136/pgmj.52.612.634.
Corticosteroid therapy is of great value in many types of eye disease. The indications are briefly discussed, together with the choice of agent and mode of administration. The dangers of steroids are now widely recognized, and the complications are discussed, particularly cataract and glaucoma. Reference is also made to optic neuritis and thyroid ophthalmopathy, where the role of steroids is uncertain. Particular stress is laid on the need to keep steroid dosage as low as possible, so as to avoid systemic side effects. There are unfortunately many situations where treatment of doubtful efficacy has produced severe side effects. Despite the overall benefit of steroids in ophthalmology, there is a pressing need to find alternative treatment for a variety of blinding disorders.
皮质类固醇疗法在多种眼科疾病中具有重要价值。本文简要讨论了其适应证,以及药物选择和给药方式。目前,类固醇的危害已得到广泛认识,文中还讨论了其并发症,尤其是白内障和青光眼。文中还提及了视神经炎和甲状腺眼病,类固醇在这些疾病中的作用尚不确定。特别强调了将类固醇剂量尽可能降低的必要性,以避免全身性副作用。不幸的是,在许多情况下,疗效存疑的治疗却产生了严重的副作用。尽管类固醇在眼科治疗中总体有益,但迫切需要为各种致盲性疾病寻找替代治疗方法。