Boros C, Hamilton S M, Katz B, Kulanthaivel P
Chemical Research Department, Sphinx Pharmaceuticals Corporation, Durham, North Carolina 27717.
J Antibiot (Tokyo). 1994 Sep;47(9):1010-6. doi: 10.7164/antibiotics.47.1010.
Recently, we reported the isolation of the potent protein kinase C inhibitor balanol (1) from the fungus Verticillium balanoides. In an earlier study, König et al. reported the isolation of ophiocordin (3), a structural isomer of 1, from the fungus Cordyceps ophioglossoides. The present study was designed to clarify whether or not balanol and ophiocordin are different compounds. The results indicated that the two fungi produced the same compound, the structure being that assigned to balanol. In addition, a thirty-fold increase in the production of balanol from V. balanoides was observed when the culture medium was changed from cornmeal/tomato paste to soy meal/glycerol.
最近，我们报道了从真菌拟轮枝镰孢菌中分离出强效蛋白激酶C抑制剂巴拉诺醇（1）。在早期的一项研究中，柯尼希等人报道了从真菌蛇形虫草中分离出1的结构异构体蛇形菌素（3）。本研究旨在阐明巴拉诺醇和蛇形菌素是否为不同的化合物。结果表明，这两种真菌产生的是同一种化合物，其结构与巴拉诺醇的结构一致。此外，当培养基从玉米粉/番茄酱改为豆粕/甘油时，观察到拟轮枝镰孢菌产生的巴拉诺醇产量增加了30倍。
