促甲状腺激素释放激素治疗脊髓性肌萎缩症的疗效
Efficacy of thyrotropin-releasing hormone in the treatment of spinal muscular atrophy.
作者信息
Takeuchi Y, Miyanomae Y, Komatsu H, Oomizono Y, Nishimura A, Okano S, Nishiki T, Sawada T
机构信息
Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.
出版信息
J Child Neurol. 1994 Jul;9(3):287-9. doi: 10.1177/088307389400900313.
Children with spinal muscular atrophy were treated by the administration of thyrotropin-releasing hormone. In three infants with spinal muscular atrophy type I, thyrotropin-releasing hormone showed little efficacy, but in children with types II and III, there was improvement in motor function and electromyographic findings after the thyrotropin-releasing hormone therapy. Thyrotropin-releasing hormone has a neurotrophic effect on the spinal anterior motor neurons of spinal muscular atrophy patients and thus may be warranted for the management of spinal muscular atrophy.
脊髓性肌萎缩症患儿接受了促甲状腺激素释放激素治疗。在3例I型脊髓性肌萎缩症婴儿中，促甲状腺激素释放激素疗效甚微，但在II型和III型患儿中，促甲状腺激素释放激素治疗后运动功能和肌电图检查结果有所改善。促甲状腺激素释放激素对脊髓性肌萎缩症患者的脊髓前运动神经元具有神经营养作用，因此可能适用于脊髓性肌萎缩症的治疗。
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