Fan P C, Lin L L
Department of Parasitology, National Yangming Medical College, Taipei, Taiwan, Republic of China.
J Helminthol. 1994 Jun;68(2):125-9. doi: 10.1017/s0022149x0001364x.
Thirty-four albino mice were each exposed to 20 cercariae of Schistosoma japonicum by the intraperitoneal or percutaneous route and killed after 60-127 days. The peritoneal cavity of each mouse was flushed and worms in the portal vein system were perfused with citrated saline. After sedimentation, washings were examined microscopically. Mature worms were only found in the portal vein system. The worm recovery rate was much higher by percutaneous infection (61.2%) than by intraperitoneal (37.1%). The encapsulated egg granulomas were observed either in the peritoneal cavity or on the intestinal wall; the mean number of encapsulated egg granulomas was also higher in the former (1.6) than in the latter (0.6). The average number of eggs per granuloma was very similar by both routes (10.7 and 11.4). The mean size of encapsulated egg granulomas (529 microns) was increased correspondingly with the number of eggs (range 181-985 microns). The percentage of viable eggs within the granulomas in the peritoneal cavity (77%) was much higher than those on the intestinal wall (18%). Encapsulated egg granulomas were usually ovoid although some had an irregular shape.
34只白化小鼠分别通过腹腔内或经皮途径感染20只日本血吸虫尾蚴，并在60 - 127天后处死。冲洗每只小鼠的腹腔，并用枸橼酸盐生理盐水灌注门静脉系统中的虫体。沉淀后，对冲洗液进行显微镜检查。仅在门静脉系统中发现成熟虫体。经皮感染的虫体回收率（61.2%）远高于腹腔内感染（37.1%）。在腹腔或肠壁上观察到包囊化虫卵肉芽肿；前者（1.6个）的包囊化虫卵肉芽肿平均数量也高于后者（0.6个）。两种途径下每个肉芽肿的平均虫卵数非常相似（分别为10.7个和11.4个）。包囊化虫卵肉芽肿的平均大小（529微米）随虫卵数量相应增加（范围为181 - 985微米）。腹腔内肉芽肿中活卵的百分比（77%）远高于肠壁上的（18%）。包囊化虫卵肉芽肿通常呈椭圆形，尽管有些形状不规则。
