Chatterjee D
Surg Gynecol Obstet. 1976 Dec;143(6):986-1000.
Idiopathic chronic gastritis is an autoimmune disease and the cause of this gastritis probably act through a final common immunologic pathway. Specific gastric antibodies are diagnostic of this gastritis and the tissue of the gastric mucosa is characterized by infiltrations of mononuclear cells damaging the glandular parenchyma with concomitant loss of gastric secretory function. With suitable predisposing factors operating, the patient with simple chronic gastritis can have pernicious anemia develop. Chronic gastritis is frequently associated with chronic gastric ulcer and carcinoma of the stomach but not with duodenal ulcer. Chronic gastritis clinically presents with vague dyspeptic symptoms. Females are more commonly affected than males and the incidence rises with advancing age. Treatment of chronic gastritis is supportive in nature and also similar to the treatment of other autoimmune diseases. The author has suggested a new treatment of duodenal ulcer whereby the patients are immunized against mucosal antigen with a view to induction of chronic gastritis. The resulting biochemical damage of the parietal cells will produce hypochlorhydria.
特发性慢性胃炎是一种自身免疫性疾病，这种胃炎的病因可能通过最终共同的免疫途径起作用。特异性胃抗体可诊断这种胃炎，胃黏膜组织的特征是单核细胞浸润，破坏腺实质，同时胃分泌功能丧失。在合适的诱发因素作用下，单纯性慢性胃炎患者可发展为恶性贫血。慢性胃炎常与慢性胃溃疡和胃癌相关，但与十二指肠溃疡无关。慢性胃炎临床上表现为模糊的消化不良症状。女性比男性更易受影响，且发病率随年龄增长而上升。慢性胃炎的治疗本质上是支持性的，也与其他自身免疫性疾病的治疗相似。作者提出了一种十二指肠溃疡的新疗法，即让患者针对黏膜抗原进行免疫，以期诱发慢性胃炎。由此导致的壁细胞生化损伤将产生胃酸过少。
