口腔鳞状细胞癌的细胞遗传学研究结果

Cytogenetic findings in squamous cell carcinoma of the oral cavity.

作者信息

Füzesi L, Braun S, Gunawan B, Schmitz H J, Mittermayer C

机构信息

Institute of Pathology, Medical School of the Technical University of Aachen, Germany.

出版信息

Int J Oral Maxillofac Surg. 1994 Jun;23(3):153-5. doi: 10.1016/s0901-5027(05)80290-5.

DOI:10.1016/s0901-5027(05)80290-5

PMID:7930768

Abstract

A case of squamous cell carcinoma (SCC) of the oral cavity is presented which, in addition to normal metaphases, cytogenetically displayed two cell clones with chromosomal aberrations: 46,XY,1+del(5)(q13),der(18)t(5;18)(q13;p11),-5 and 49,XY,+5,+7,+10 After a review of the literature of the few cytogenetically analyzed cases, the findings confirm the multiclonal origin of oral SCC and also the commonly seen aberrations of chromosome 5.

摘要

本文报告了一例口腔鳞状细胞癌（SCC）病例，除正常中期细胞外，细胞遗传学显示有两个带有染色体畸变的细胞克隆：46,XY,1+del(5)(q13),der(18)t(5;18)(q13;p11),-5和49,XY,+5,+7,+10。在回顾少数经细胞遗传学分析的病例文献后，这些发现证实了口腔SCC的多克隆起源以及常见的5号染色体畸变。