Medrano G A, de Micheli A
National Institute of Cardiology Ignacio Chávez, México, DF.
J Electrocardiol. 1994 Jul;27(3):263-73. doi: 10.1016/s0022-0736(94)80011-1.
Chemical necrosis was produced with the infiltration of 96 degrees alcohol on the middle anterosuperior segment 5 (nomenclature of the International Society for Computerized Electrocardiology) of the free left ventricular (LV) wall in 45 dogs and on the apical segment 10 and middle posterolateral segment 11 in 30 others. In five animals from each group, a 10 bipolar arrow assembly was used to obtain Purkinje fiber potentials and to determine the degree to which QS complexes are recorded from the inner portions of the free LV wall. When transmural necrosis was present, QS complexes were generally obtained in both the epicardial and thoracic leads. Subendocardial necrosis was manifested by qrS complexes on the epicardium, as well as in the peripheral leads. When the posterolateral middle third of the LV wall was damaged, Rs or qRs complexes were recorded in leads II, III, and aVF, and an increase in the voltage of the R wave in leads V1 and V2 was observed. Intramural myocardial necrosis diminished the voltage of the R wave in the corresponding leads. Left peripheral blocks obscured the manifestation of myocardial necrosis.
对45只犬的左心室（LV）游离壁前上中段5（国际计算机化心电学会命名法）注入96度酒精造成化学性坏死，对另外30只犬的心尖段10和后外侧中段11注入酒精造成坏死。每组选取5只动物，使用10极双极电极装置获取浦肯野纤维电位，并确定从左心室游离壁内部记录到QS波群的程度。当出现透壁性坏死时，在心外膜导联和胸导联通常均可记录到QS波群。心内膜下坏死表现为心外膜导联以及外周导联出现qrS波群。当左心室壁后外侧中三分之一受损时，在Ⅱ、Ⅲ和aVF导联记录到Rs或qRs波群，并且观察到V1和V2导联R波电压升高。壁内心肌坏死使相应导联的R波电压降低。左束支阻滞掩盖了心肌坏死的表现。
