通过长期抑制单胺氧化酶A对大脑皮质去甲肾上腺素释放的调节

Modification of cerebral cortical noradrenaline release by chronic inhibition of MAO-A.

作者信息

Finberg J P, Pacak K, Goldstein D S, Kopin I J

机构信息

Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.

出版信息

J Neural Transm Suppl. 1994;41:123-5. doi: 10.1007/978-3-7091-9324-2_16.

DOI:10.1007/978-3-7091-9324-2_16

PMID:7931217

Abstract

Chronic treatment of rats with clorgyline (1 mg/kg i.p. daily for 21 days) caused a highly significant increase in the concentration of noradrenaline in microdialysate from the frontal cortex of the awake animal. Acute (one injection, 2 mg/kg) or subacute (1 mg/kg daily for 3 days) treatment did not lead to a significant increase in microdialysate noradrenaline. Concentrations of deaminated metabolites (DPHG, MHPG, DOPAC) in the microdialysate decreased with time of treatment, reaching a minimum after 21 days.

摘要

用氯吉兰对大鼠进行慢性处理（每天腹腔注射1毫克/千克，持续21天），导致清醒动物额叶皮质微透析液中去甲肾上腺素浓度显著升高。急性处理（单次注射，2毫克/千克）或亚急性处理（每天1毫克/千克，持续3天）并未导致微透析液中去甲肾上腺素显著增加。微透析液中脱氨基代谢物（DPHG、MHPG、DOPAC）的浓度随处理时间下降，在21天后降至最低。