吗氯贝胺对大鼠松果体褪黑素生物合成影响的时辰药理学研究。
Chronopharmacological study of moclobemide effect on the rat pineal melatonin biosynthesis.
作者信息
Oxenkrug G F, Requintina P J, White K, Yuwiler A
机构信息
Pineal Research Laboratory, VAMC, Providence, Rhode Island.
出版信息
J Neural Transm Suppl. 1994;41:335-7. doi: 10.1007/978-3-7091-9324-2_44.
The chronopharmacological hypothesis of the mechanism of the antidepressant effect of MAO-A inhibitors predicts that clinical efficacy depends upon the time of the day at which the drugs are administered. In the present study moclobemide (10 mg/kg, s.c.) injected at the end of the light phase advanced the onset of the nighttime increase of the rat pineal melatonin biosynthesis while the same dose of drug injected at the end of the dark phase delayed the daytime decrease of melatonin biosynthesis. The results obtained suggest that the timing of MAO-A inhibitor administration should be considered in clinical practice.
单胺氧化酶A抑制剂抗抑郁作用机制的时辰药理学假说预测，临床疗效取决于给药的时间。在本研究中，于光照期结束时皮下注射吗氯贝胺（10毫克/千克）可提前大鼠松果体褪黑素生物合成夜间增加的起始时间，而在黑暗期结束时注射相同剂量的药物则会延迟褪黑素生物合成的日间减少。所得结果表明，在临床实践中应考虑单胺氧化酶A抑制剂的给药时间。
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