Oxenkrug G F, Requintina P J
Department of Psychiatry, St. Elizabeth's Medical Center of Boston/Tufts University, MA, USA.
J Neural Transm Suppl. 1998;52:333-6. doi: 10.1007/978-3-7091-6499-0_35.
Selective monoamine oxidase (MAO) A inhibitors and cold-immobilization stress (which increases the production of the endogenous MAO-A inhibitor, tribulin) stimulate rat pineal melatonin biosynthesis in Sprague-Dawley and Fisher 344N rats. Considering the hyperactive sympathetic response of the hypertensive rats, it was interesting to compare the effect of clorgyline and cold-immobilization stress on pineal melatonin and related indoles levels in SHR and WKY rats (HPLC-fluorimetric method). Clorgyline (0.5 mg/kg and 1.5 mg/kg, sc) induced a higher elevation of pineal melatonin and N-acetylserotonin (NAS) in SHR than in WKY rats. Cold immobilization stress resulted in lower serotonin, and higher NAS levels in SHR than in WKY rats with similar elevations in melatonin levels. Our results suggest increased serotonin conversion into NAS and decreased NAS conversion into melatonin with decreased production of tribulin in SHR in comparison with WKY rats.
选择性单胺氧化酶（MAO）A抑制剂和冷束缚应激（可增加内源性MAO - A抑制剂tribulin的产生）可刺激斯普拉格-道利大鼠和费希尔344N大鼠的松果体褪黑素生物合成。考虑到高血压大鼠的交感神经反应亢进，比较氯吉兰和冷束缚应激对自发性高血压大鼠（SHR）和Wistar - Kyoto大鼠（WKY）松果体褪黑素及相关吲哚水平的影响很有意思（采用高效液相色谱-荧光法）。氯吉兰（0.5毫克/千克和1.5毫克/千克，皮下注射）在SHR中诱导的松果体褪黑素和N - 乙酰血清素（NAS）升高幅度高于WKY大鼠。冷束缚应激导致SHR中的血清素水平较低，NAS水平较高，而褪黑素水平升高幅度与WKY大鼠相似。我们的结果表明，与WKY大鼠相比，SHR中血清素向NAS的转化增加，NAS向褪黑素的转化减少，且tribulin的产生减少。
