与肠上皮细胞发育状态相关的黄素腺嘌呤二核苷酸依赖的胺氧化酶

The FAD dependent amine oxidases in relation to developmental state of enterocyte.

作者信息

Fogel W A, Maslinski C

机构信息

Department of Biogenic Amines, Polish Academy of Sciences, Lodz.

出版信息

J Neural Transm Suppl. 1994;41:95-9. doi: 10.1007/978-3-7091-9324-2_12.

DOI:10.1007/978-3-7091-9324-2_12

PMID:7931271

Abstract

Epithelial cells from bovine and guinea pig small intestines contain monoamine and polyamine oxidases with MAO-A preponderance at any maturational stage. For either species, Km values for 5HT and N1acetylspermine remain throughout cellular maturation on the same levels, whereas the Vmax values do not. For serotonin, the dividing crypt cells showed in cow lower and in guinea pig higher Vmax than the mature cells; for N1acetylspermine, mature cells, independently of species, showed lower Vmax.

摘要

牛和豚鼠小肠的上皮细胞在任何成熟阶段都含有单胺氧化酶和多胺氧化酶，且以MAO - A为主。对于这两个物种中的任何一个，5 - 羟色胺（5HT）和N1 - 乙酰精胺的米氏常数（Km值）在细胞成熟过程中保持在相同水平，而最大反应速度（Vmax值）则不然。对于血清素，牛的分裂隐窝细胞的Vmax低于成熟细胞，而豚鼠的分裂隐窝细胞的Vmax高于成熟细胞；对于N1 - 乙酰精胺，成熟细胞的Vmax较低，与物种无关。