Takagi T, Yoshikawa J, Yoshida K, Akasaka T, Honda Y, Maenishi A
Department of Cardiology, Kobe General Hospital.
J Cardiol. 1994 Sep-Oct;24(5):347-55.
The value of dobutamine stress echocardiography for detecting coronary artery disease was evaluated in 67 patients with normal left ventricular wall motion at rest who also underwent quantitative angiography. The overall sensitivity and specificity of dobutamine stress echocardiography for detecting coronary artery disease were 83% and 70%, respectively. The sensitivities for detecting multivessel disease and single vessel disease were 92% and 76%, respectively. The sensitivity of dobutamine stress echocardiography was 91% in patients treated without beta-blocker, and 70% in patients treated with beta-blocker (p < 0.001). The relatively low peak heart rate during dobutamine infusion in patients treated with beta-blocker seems to affect the sensitivity of dobutamine stress echocardiography. There were no severe complications during dobutamine infusion. Dobutamine stress echocardiography is a safe and accurate method for detecting coronary artery disease. However, an additional technique to increase peak heart rate in patients treated with beta-blocker such as injection of atropin should be considered.
对67例静息时左心室壁运动正常且同时接受定量血管造影的患者，评估了多巴酚丁胺负荷超声心动图检测冠状动脉疾病的价值。多巴酚丁胺负荷超声心动图检测冠状动脉疾病的总体敏感性和特异性分别为83%和70%。检测多支血管病变和单支血管病变的敏感性分别为92%和76%。未接受β受体阻滞剂治疗的患者中，多巴酚丁胺负荷超声心动图的敏感性为91%，接受β受体阻滞剂治疗的患者中为70%（p<0.001）。接受β受体阻滞剂治疗的患者在多巴酚丁胺输注期间相对较低的峰值心率似乎影响了多巴酚丁胺负荷超声心动图的敏感性。多巴酚丁胺输注期间未出现严重并发症。多巴酚丁胺负荷超声心动图是检测冠状动脉疾病的一种安全且准确的方法。然而，应考虑采用额外的技术来提高接受β受体阻滞剂治疗患者的峰值心率，如注射阿托品。
