Riemann D, Hohagen F, Krieger S, Gann H, Müller W E, Olbrich R, Wark H J, Bohus M, Löw H, Berger M
Psychiatric Clinic, University of Freiburg, Germany.
J Psychiatr Res. 1994 May-Jun;28(3):195-210. doi: 10.1016/0022-3956(94)90006-x.
Disinhibition of rapid eye movement (REM) sleep (e.g. shortening of REM latency, heightened REM density) is frequently encountered in patients with a major depressive disorder (MDD). Administration of cholinomimetics prior to or during sleep leads to a more pronounced advance of REM sleep in depressed patients compared to healthy controls and patients with other psychiatric disorders. The present study tested whether the cholinergic REM induction test (CRIT) with 1.5 mg RS 86 (an orally acting muscarinic agonist) differentiates patients with MDD (n = 40) from those with schizophrenia (n = 43) and healthy controls (n = 36). The most pronounced shortening of REM latency after cholinergic stimulation occurred in patients with MDD. However, a significant number of patients with schizophrenia also displayed short REM latencies (REM latency < 25 minutes) under placebo conditions and after cholinergic stimulation. REM density measures more clearly differentiated patients with MDD from those with schizophrenia. It is concluded that a subgroup of patients suffering from schizophrenia displays signs of a muscarinic receptor supersensitivity.
快速眼动（REM）睡眠脱抑制（如REM潜伏期缩短、REM密度增加）在重度抑郁症（MDD）患者中经常出现。与健康对照者和患有其他精神疾病的患者相比，在睡眠前或睡眠期间给予拟胆碱药会使抑郁症患者的REM睡眠提前更为明显。本研究测试了使用1.5毫克RS 86（一种口服作用的毒蕈碱激动剂）进行胆碱能REM诱导试验（CRIT）能否区分MDD患者（n = 40）、精神分裂症患者（n = 43）和健康对照者（n = 36）。胆碱能刺激后，MDD患者的REM潜伏期缩短最为明显。然而，相当数量的精神分裂症患者在安慰剂条件下以及胆碱能刺激后也表现出较短的REM潜伏期（REM潜伏期<25分钟）。REM密度测量能更清楚地区分MDD患者和精神分裂症患者。得出的结论是，一部分精神分裂症患者表现出毒蕈碱受体超敏的迹象。
