BUF大鼠的自发性自身免疫性甲状腺炎
Spontaneous autoimmune thyroiditis in the BUF rat.
作者信息
Rose N R, Bigazzi P E, Noble B
出版信息
Adv Exp Med Biol. 1976;73 Pt B:209-16. doi: 10.1007/978-1-4684-3300-5_18.
The inbred BUF rat develops autoimmune thyroiditis spontaneously. The incidence is related to the age of the animal and is increased by neonatal thymectomy and by treatment with methylcholanthrene. Autoantibodies to thyroglobulin can be demonstrated by indirect immunofluorescence and hemagglutination, but skin tests are negative. The "spontaneous" autoimmune disease may be due to the conjunction of an unusually vigorous immunological response to thyroglobulin and the loss of thymic suppressor function.
近交系BUF大鼠会自发发生自身免疫性甲状腺炎。发病率与动物年龄有关，新生期胸腺切除和用甲基胆蒽处理可使其发病率增加。甲状腺球蛋白自身抗体可用间接免疫荧光和血凝反应检测到，但皮肤试验为阴性。这种“自发”的自身免疫性疾病可能是由于对甲状腺球蛋白的异常强烈免疫反应与胸腺抑制功能丧失共同作用的结果。
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