Mori M, Kitano T, Iwasaka H, Noguchi T, Honda N, Soeda T, Hadama T
Department of Anesthesiology, Oita Medical University.
Masui. 1994 Jul;43(7):1029-32.
Effect of pirenzepine on gastric mucosal blood flow (GMBF) in adult patients after coronary artery bypass grafting and mitral and aortic valve replacement was evaluated by using endoscopic laser-Doppler velocimetry. Heart rate, blood pressure and cardiac output increased temporarily after intravenous administration of pirenzepine 20 mg. GMBF also increased with these hemodynamic changes. However, GMBF remained significantly higher even after the decrease of cardiac output. Therefore, the increase in GMBF, which might be due in part to increase in cardiac output, could be explained by pirenzepine's own effect on gastric mucosa. Since the GMBF is one of the most important gastric mucosal defensive factors, pirenzepine may be useful in preventing acute gastric mucosal lesions in patients with low cardiac output.
采用内镜激光多普勒测速法评估了哌仑西平对冠状动脉搭桥术及二尖瓣和主动脉瓣置换术后成年患者胃黏膜血流量（GMBF）的影响。静脉注射20mg哌仑西平后，心率、血压和心输出量暂时升高。GMBF也随着这些血流动力学变化而增加。然而，即使在心输出量下降后，GMBF仍显著升高。因此，GMBF的增加可能部分归因于心输出量的增加，也可以用哌仑西平对胃黏膜的自身作用来解释。由于GMBF是最重要的胃黏膜防御因素之一，哌仑西平可能有助于预防心输出量低的患者发生急性胃黏膜病变。
