Takakuwa Y, Miyazawa K, Yoshikawa O, Toyama K
First Department of Internal Medicine, Tokyo Medical College.
Rinsho Ketsueki. 1994 Aug;35(8):744-50.
Serum ferritin concentration had been known to represent the amount of total body iron and has been clinically used as a parameter to evaluate the iron storage pool in a whole body. Glycosylated (secreted) and non-glycosylated (non-secreted) forms of serum ferritin (sFt) have been reported by others based on the difference in their affinity to concanavalin-A binding. In this report, we assessed the amount of glycosylated serum ferritin (Glyco-sFt) and the ratio (%) of Glyco-sFt/in hematopoietic disorders including iron overloads (n = 10), leukemias (n = 36), malignant lymphomas (n = 10), multiple myelomas (n = 3) and myelodysplastic syndromes (n = 12). A high percentage of Glyco-sFt was observed in normal healthy controls (n = 18, 78.1 +/- 7.4%) and iron-overloads (61.1 +/- 17.8%) as compared with that in hematopoietic malignancies (43.8 +/- 23.4%, p < 0.001). The amount of Glyco-sFt in iron-overloads was higher than that in hematopoietic malignancies with hyperferritinemia (p < 0.005). These data demonstrated that the same part of serum ferritin in hematopoietic malignancies was the non-secreted form and appeared to be derived from tumor cell lysis. We conclude that assessment of Glyco-Ft is a useful parameter to distinguish iron-overloads from malignant hematopoietic disorders both displaying hyperferritinemia.
血清铁蛋白浓度一直被认为可代表全身铁含量，并在临床上用作评估全身铁储存池的一个参数。其他人已根据血清铁蛋白（sFt）的糖基化（分泌型）和非糖基化（非分泌型）形式对刀豆球蛋白-A结合的亲和力差异进行了报道。在本报告中，我们评估了糖基化血清铁蛋白（Glyco-sFt）的含量以及Glyco-sFt/总血清铁蛋白在包括铁过载（n = 10）、白血病（n = 36）、恶性淋巴瘤（n = 10）、多发性骨髓瘤（n = 3）和骨髓增生异常综合征（n = 12）在内的造血系统疾病中的比例（%）。与造血系统恶性肿瘤（43.8 +/- 23.4%，p < 0.001）相比，在正常健康对照者（n = 18，78.1 +/- 7.4%）和铁过载患者（61.1 +/- 17.8%）中观察到较高比例的Glyco-sFt。铁过载患者的Glyco-sFt含量高于伴有高铁蛋白血症的造血系统恶性肿瘤患者（p < 0.005）。这些数据表明，造血系统恶性肿瘤中血清铁蛋白的同一部分为非分泌型，似乎来源于肿瘤细胞裂解。我们得出结论，评估Glyco-Ft是区分均表现为高铁蛋白血症的铁过载和恶性造血系统疾病的一个有用参数。
