Akimoto Y, Ishiyama T, Ueno H, Hino K, Tomoyasu S, Tsuruoka N, Kushima M, Kazama K
Department of Hematology, Showa University School of Medicine.
Rinsho Ketsueki. 1994 Aug;35(8):780-5.
Cases of pure red cell aplasia with thymoma and myasthenia gravis are rare. We described a patient who had concomitant pure red cell aplasia, thymoma, myasthenia gravis and a normal pressure hydrocephalus. A 63-year-old man with disturbances of gait, left blepharoptosis and anemia was presented to our hospital. Laboratory examination on admission revealed severe anemia. Bone marrow aspirates showed erythroid hypoplasia of marked degree. Chest x-ray and chest CT revealed a tumor to the right of cardiac wall. The tensilon chloride test and antiacetylcholine receptor antibody were positive. A hydrocephalus was demonstrated with brain CT. Cerebrospinal fluid pressure was in the normal range. He was diagnosed as having pure red cell aplasia with thymoma, myasthenia gravis and a normal pressure hydrocephalus. This appears to be a fairly rare case. It seems important to consider that a normal pressure hydrocephalus may have immunological disorders.
伴有胸腺瘤和重症肌无力的纯红细胞再生障碍性贫血病例较为罕见。我们描述了一位同时患有纯红细胞再生障碍性贫血、胸腺瘤、重症肌无力和正常压力脑积水的患者。一名63岁男性因步态障碍、左眼睑下垂和贫血前来我院就诊。入院时实验室检查显示严重贫血。骨髓穿刺显示红细胞生成显著低下。胸部X线和胸部CT显示心壁右侧有一个肿瘤。氯化腾喜龙试验和抗乙酰胆碱受体抗体呈阳性。脑部CT显示有脑积水。脑脊液压力在正常范围内。他被诊断为患有伴有胸腺瘤、重症肌无力和正常压力脑积水的纯红细胞再生障碍性贫血。这似乎是一个相当罕见的病例。考虑到正常压力脑积水可能存在免疫紊乱似乎很重要。
