Miyauchi Y
First Department of Surgery, Kumamoto University School of Medicine.
Nihon Rinsho. 1994 Aug;52(8):2182-6.
The clinical usefulness of prostaglandin derivatives was reviewed for the treatment of peripheral vascular diseases such as arteriosclerosis obliterans, Buerger's disease, Raynaud's disease, and collagen disease etc. PGE1 was initially used for this purpose, however, it had to be infused intra-arterially or intravenously for hours. PGE1 incorporated in lipid microsphere (Lipo PGE1) was made for one-shot use and the targeting drug delivery because the lipid microsphere is easily taken up by some inflammatory cells. Lipo PGE1 was revealed to be effective to improvement of considerably large ischemic ulcer and pain. Beraprost sodium (PGI2 derivative) was produced for oral use, and has been widely used. The effectiveness was similar to Lipo PGE1, but the complications such as hypotension, headache, and numbness were more common in PGI2.
对前列腺素衍生物在治疗外周血管疾病（如闭塞性动脉硬化、血栓闭塞性脉管炎、雷诺病和胶原病等）方面的临床实用性进行了综述。前列腺素E1（PGE1）最初用于此目的，然而，它必须通过动脉内或静脉内输注数小时。脂质微球包裹的PGE1（前列地尔脂微球制剂）制成一次性使用剂型并用于靶向给药，因为脂质微球容易被某些炎症细胞摄取。前列地尔脂微球制剂被证明对改善相当大的缺血性溃疡和疼痛有效。贝前列素钠（前列环素（PGI2）衍生物）制成口服剂型并已被广泛使用。其有效性与前列地尔脂微球制剂相似，但PGI2更常出现低血压、头痛和麻木等并发症。
