Yokose N, Ogata K, Ito T, An E, Tamura H, Dan K, Hamaguchi H, Sakamaki H, Onozawa Y, Nomura T
Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
Leuk Res. 1994 Oct;18(10):777-82. doi: 10.1016/0145-2126(94)90060-4.
The plasma soluble interleukin 2 receptor (sIL-2R) level and its relationships with haematologic and immunologic data were examined in 40 patients with myelodysplastic syndromes (MDS). The plasma sIL-2R level was significantly higher in the high-risk MDS group (refractory anaemia with excess blasts (RAEB), RAEB in transformation and chronic myelomonocytic leukaemia) than in the low-risk MDS group (refractory anaemia (RA) and RA with ringed sideroblasts) or in normal subjects, although there was considerable variation in the plasma sIL-2R level within each MDS group. The plasma sIL-2R level correlated positively with the bone marrow cellularity and bone marrow blast mass, but not with the absolute number of CD25+ lymphocytes. This may support the idea that plasma sIL-2R is derived from malignant MDS cells in the bone marrow. The plasma sIL-2R level correlated negatively with the absolute numbers of the CD8+, CD3-CD16+, and CD3-CD56+ cell populations in freshly isolated lymphocytes, the percentage of CD3-CD56+ cells in lymphokine (interleukin 2)-activated killer (LAK) cells, and the cytotoxicity of LAK cells. We conclude that MDS patients having a high plasma sIL-2R level often have a defect in natural killer and CD8+ T-cells.
对40例骨髓增生异常综合征（MDS）患者检测了血浆可溶性白细胞介素2受体（sIL-2R）水平及其与血液学和免疫学数据的关系。高危MDS组（难治性贫血伴原始细胞增多（RAEB）、转化中的RAEB和慢性粒-单核细胞白血病）的血浆sIL-2R水平显著高于低危MDS组（难治性贫血（RA）和环形铁粒幼细胞性RA）或正常受试者，尽管每个MDS组内血浆sIL-2R水平存在相当大的差异。血浆sIL-2R水平与骨髓细胞密度和骨髓原始细胞量呈正相关，但与CD25+淋巴细胞绝对数无关。这可能支持血浆sIL-2R来源于骨髓中恶性MDS细胞的观点。血浆sIL-2R水平与新鲜分离淋巴细胞中CD8+、CD3-CD16+和CD3-CD56+细胞群的绝对数、淋巴因子（白细胞介素2）激活的杀伤细胞（LAK细胞）中CD3-CD56+细胞的百分比以及LAK细胞的细胞毒性呈负相关。我们得出结论，血浆sIL-2R水平高的MDS患者通常存在自然杀伤细胞和CD8+T细胞缺陷。
